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Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
General Structure of a Vertebra01:30

General Structure of a Vertebra

A typical vertebra, with the exception of the sacrum and coccyx, consists of a body, a vertebral arch, and seven different projections termed processes. The anterior portion of the vertebrae, the body, supports about half the body’s weight. The vertebral bodies progressively increase in size and thickness from the cervical region to the lumbar region of the vertebral column. The intervertebral discs present between the bodies of adjacent vertebrae firmly unites them, forming a continuous column.
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jun 16, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
03:47

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

Published on: October 25, 2024

Odontoid process pathologic fracture in spinal tuberculosis.

M Ould-Slimane1, T Lenoir, C Dauzac

  • 1Service de chirurgie orthopédique, hôpital Beaujon, Assistance publique-Hôpitaux de Paris, université Paris-VII, 100, boulevard du Général-Leclerc, 92110 Clichy, France.

Orthopaedics & Traumatology, Surgery & Research : OTSR
|February 23, 2010
PubMed
Summary
This summary is machine-generated.

Craniovertebral junction tuberculosis is rare, with controversial treatment options. This case highlights an unusual odontoid fracture and neurological progression in spinal tuberculosis, a condition with few reported instances.

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Last Updated: Jun 16, 2026

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
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Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Area of Science:

  • Neurology
  • Infectious Diseases
  • Orthopedic Surgery

Background:

  • Craniovertebral junction tuberculosis is an uncommon condition with debated treatment strategies, ranging from conservative management to surgical intervention.
  • The management approach often does not consider the presence or absence of neurological compromise.

Observation:

  • This report details the first documented case of a pathologic odontoid fracture occurring within the context of spinal tuberculosis.
  • The patient exhibited an unusual neurological evolution secondary to the fracture and tuberculosis.

Findings:

  • The patient presented with non-contiguous multifocal tuberculosis, a rare presentation with only six previous cases documented in medical literature.
  • The combination of craniovertebral junction tuberculosis, odontoid fracture, and complex neurological sequelae is exceptionally rare.

Implications:

  • This case underscores the need for considering diverse clinical presentations and potential complications in craniovertebral junction tuberculosis.
  • Further research may be warranted to refine treatment protocols for this rare and complex spinal infection, particularly when associated with fractures and neurological deficits.