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Updated: Jun 16, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
Published on: March 28, 2025
Exogenous allogenic fragmented double-stranded DNA is internalized into human dendritic cells and enhances their
Ekaterina A Alyamkina1, Evgenia V Dolgova, Anastasia S Likhacheva
1Novosibirsk State University, Novosibirsk, Russia.
Abstract:
Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli.
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