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[Endobronchial drug administration in resuscitation]
1Institut für Anästhesiologie, Universität Würzburg.
Medizinische Klinik (Munich, Germany : 1983)
|January 15, 1991
Summary
Endobronchial drug delivery is effective when intravenous access is not possible. Studies show deep endobronchial instillation achieves significant lung surface area distribution for drug absorption during resuscitation.
Area of Science:
- Pulmonology
- Pharmacology
- Anatomy
Context:
- Endobronchial drug administration is a viable alternative route during pharmacological resuscitation, especially when venous access is challenging.
- Assessing the distribution and resorption surface area of drugs instilled deep into the bronchi is crucial for optimizing treatment efficacy.
Purpose:
- To quantify the distribution area of methylen-blue after deep endobronchial instillation in human cadavers.
- To evaluate the potential for sufficient pulmonary surface area coverage for drug resorption during resuscitation.
Summary:
- Twelve human cadavers were intubated and received methylen-blue via a specialized endobronchial application kit.
- Results demonstrated excellent distribution (90-100%) in the main bronchi (bronchi principals dexter and sinister).
- Over 70% of the lobar bronchi in both right and left bronchial trees were reached, indicating substantial lung surface area coverage.
Impact:
- The study confirms that deep endobronchial instillation provides adequate lung surface area for drug absorption in a non-circulating, horizontal patient.
- This supports the use of endobronchial drug delivery as an effective resuscitation method when intravenous access is not feasible.