Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic test accuracies of 4AT items are consistent across the range of baseline cognition: results from two prospective studies.

Age and ageing·2026
Same author

A Comparative Analysis of Hospital-Acquired Complications and Sentinel Event Reporting Across Australia, Canada, New Zealand, England, and the United States.

Joint Commission journal on quality and patient safety·2026
Same author

Delirium: more than a marker of baseline vulnerability.

Age and ageing·2026
Same author

The epidemiology and outcomes of periprosthetic femur fractures : the Scottish National Audit of Periprosthetic Femur Fractures (SNAP Femur) study.

The bone & joint journal·2026
Same author

Prevalence and outcomes of recorded dementia vary by data source: a population cohort study of 133 407 older adults.

Age and ageing·2026
Same author

Is delirium after stroke associated with dysregulation of hypothalamic pituitary axis?

Frontiers in stroke·2026

Related Experiment Video

Updated: Jun 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Quantifying the effects of normal ageing on white matter structure using unsupervised tract shape modelling.

Mark E Bastin1, Susana Muñoz Maniega, Karen J Ferguson

  • 1Medical and Radiological Sciences (Medical Physics), University of Edinburgh, and Western General Hospital, Edinburgh, UK. Mark.Bastin@ed.ac.uk

Neuroimage
|February 23, 2010
PubMed
Summary

Brain atrophy and white matter lesions significantly alter white matter tract shape and integrity in older adults. These changes, particularly in the corpus callosum, are linked to aging and brain volume reduction.

More Related Videos

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Aging Research

Background:

  • Normal aging involves changes in white matter structure.
  • Understanding regional variations in white matter integrity is crucial for aging research.
  • Brain atrophy and white matter lesions are common in older adults.

Purpose of the Study:

  • To investigate how brain atrophy and white matter lesions influence white matter tract shape and integrity in non-demented older adults.
  • To examine age-related correlations between tract shape, integrity, and brain structural changes.
  • To assess the impact of global atrophy and ventricular enlargement on age-related white matter changes.

Main Methods:

  • Utilized an enhanced probabilistic neighborhood tractography method for reliable tract segmentation.
  • Employed unsupervised learning and streamline selection for automatic seed point placement.
  • Compared tract shape to a young brain white matter atlas and analyzed correlations with age, mean diffusivity (D), and fractional anisotropy (FA).

Main Results:

  • Significant negative correlations between tract shape similarity and age were found in the genu and splenium of the corpus callosum.
  • Global atrophy and ventricular enlargement significantly attenuated these callosal tract correlations.
  • Age-related increases in mean diffusivity (D) and decreases in fractional anisotropy (FA) were observed in the corpus callosum genu, but not the splenium.

Conclusions:

  • Brain atrophy and white matter lesions are key drivers of age-related changes in white matter tract shape and integrity.
  • Age-related white matter alterations show regional heterogeneity, influenced by global brain changes.
  • The findings support the
  • frontal aging
  • hypothesis and highlight the role of structural changes in cognitive aging.