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Use of normal tissue complication probability models in the clinic
Lawrence B Marks1, Ellen D Yorke, Andrew Jackson
1Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu
International Journal of Radiation Oncology, Biology, Physics
|February 23, 2010
Summary
The QUANTEC review updates normal tissue tolerance guidelines using 3D dose/volume/outcome data. It provides clinicians with practical information on normal tissue complication probability (NTCP) models for responsible use in radiotherapy.
Area of Science:
- Radiation Oncology
- Medical Physics
- Clinical Radiation Oncology
Background:
- The 1991 Emami et al. paper established classic normal tissue tolerance guidelines.
- Advancements in 3D imaging and treatment planning necessitate updated guidelines.
- Accurate normal tissue complication probability (NTCP) modeling is crucial for radiotherapy.
Purpose of the Study:
- To update and refine normal tissue dose/volume tolerance guidelines.
- To provide a clinician-oriented perspective on utilizing QUANTEC data.
- To summarize organ-specific dose/volume/outcome relationships.
Main Methods:
- Comprehensive review of existing 3D dose/volume/outcome data.
- Analysis and synthesis of data from the QUANTEC initiative.
- Description and evaluation of commonly used NTCP models.
Main Results:
- Updated dose/volume tolerance guidelines for various normal tissues.
- Summarized organ-specific dose/volume/outcome data.
- Practical considerations for applying QUANTEC findings in clinical practice.
Conclusions:
- QUANTEC provides essential updates to radiotherapy normal tissue tolerance.
- Clinicians can responsibly use QUANTEC data with NTCP models.
- Refined guidelines improve patient safety and treatment efficacy.
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