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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume

Søren M Bentzen1, Matthew Parliament, Joseph O Deasy

  • 1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA. bentzen@humonc.wisc.edu

International Journal of Radiation Oncology, Biology, Physics
|February 23, 2010
PubMed

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Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...