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Transconjunctival Approach for Injection into the Rat Optic Nerve
Published on: April 4, 2025
Radiation dose-volume effects of optic nerves and chiasm
Charles Mayo1, Mary K Martel, Lawrence B Marks
1Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA. charles.mayo@umassmemorial.org
None:
Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.
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