Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Reply to DeLaney.

International journal of radiation oncology, biology, physics·2026
Same author

Increased frequency of remote and off-site work impacts incident learning workflows in radiation oncology.

Technical innovations & patient support in radiation oncology·2026
Same author

High-Dose Twice-Daily Thoracic Radiotherapy for Limited-Stage Small-Cell Lung Cancer: A Real-World Retrospective Experience from Two Tertiary Centers.

OncoTargets and therapy·2026
Same author

Navigating Variability in Prostate RT Planning: Real-Time Insights for Human-Centered CDS Design.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same author

Reirradiation Collaborative Group (ReCOG) consensus on standards for dose evaluation and reporting in patients with multiple courses of radiation therapy: an AAPM/ACRO/ASTRO/CARO/COMP/CADRA/CPQR/ESTRO/NRG-endorsed consensus statement.

The Lancet. Oncology·2026
Same author

Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.

Cell genomics·2026

Related Experiment Video

Updated: Jun 16, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Radiation dose-volume effects in the heart.

Giovanna Gagliardi1, Louis S Constine, Vitali Moiseenko

  • 1Department of Medical Physics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden. giovanna.gagliardi@karolinska.se

International Journal of Radiation Oncology, Biology, Physics
|February 23, 2010
PubMed
Summary

Predicting radiation-induced heart disease is challenging due to limited data. Clinical factors like age and doxorubicin use increase risk, but clear dose-volume predictors for cardiac toxicity remain elusive.

More Related Videos

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
06:08

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
06:08

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

Published on: May 26, 2019

Area of Science:

  • Cardiology
  • Radiation Oncology
  • Medical Physics

Background:

  • Radiation therapy can cause heart damage.
  • Understanding predictors of cardiac toxicity is crucial for patient safety.

Purpose of the Study:

  • To review clinical and dose-volume predictors of radiation-induced heart disease.
  • To identify gaps in current knowledge and suggest future research directions.

Main Methods:

  • Literature review of existing studies on radiation-induced heart disease.
  • Analysis of clinical factors and dose-volume parameters associated with cardiac toxicity.

Main Results:

  • Limited data exists to establish clear quantitative dose-volume relationships for cardiac toxicity.
  • Clinical factors such as patient age, comorbidities, and prior doxorubicin treatment appear to elevate the risk of heart injury.

Conclusions:

  • Further research is needed to better define the dose-volume parameters influencing radiation-induced cardiac injury.
  • Clinical factors play a significant role in modifying cardiac risk.