Related Experiment Video
Updated: Jun 16, 2026

Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
Promoting implantation by local injury to the endometrium
Benjamin Almog1, Einat Shalom-Paz, Daniel Dufort
1Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Objective:
To evaluate the association between endometrial injury, implantation and pregnancy rate.
Design:
We performed a literature search using the keywords endometrial injury, local endometrial injury, endometrial biopsy, endometrial receptivity, implantation, in vitro fertilization, and implantation failure and conducted the search in Medline, EMBASE, and Cochrane Database of systematic reviews.
Setting:
None.
Patient(S):
None.
Intervention(S):
None.
Main Outcome Measure(S):
None.
Result(S):
Clinical and basic science data regarding the association between endometrial injury and improved implantation rate are limited. However, current evidence suggests that endometrial injury before IVF among women with previous repeated IVF failure is associated with increased rates of implantation, clinical pregnancy, and live birth.
Conclusion(S):
Endometrial injury may have a beneficial role in implantation and improve the pregnancy rate. However, there are still many unanswered question including patients selection, timing, technique and number of endometrial biopsies needed.
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