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Elevated serum IL-8 levels in ataxia telangiectasia
Sharon A McGrath-Morrow1, J Michael Collaco, Thomas O Crawford
1Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. smorrow@jhmi.edu
The Journal of Pediatrics
|February 23, 2010
Abstract:
Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.