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Related Experiment Video

Updated: Jun 16, 2026

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

Bladder afferent signaling: recent findings.

Anthony Kanai¹, Karl-Erik Andersson

¹Department of Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. ajk5@pitt.edu

The Journal of Urology

|February 23, 2010

Summary

This summary is machine-generated.

Understanding bladder afferent mechanisms is key to controlling dysfunctional micturition. Research identifies urothelial and myogenic pathways transmitting signals to the central nervous system.

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Area of Science:

Lower urinary tract physiology
Neuroscience
Urology

Background:

Current research emphasizes afferent mechanisms in lower urinary tract physiology.
Defining and controlling signaling pathways for afferent information is a primary goal.

Purpose of the Study:

To summarize recent research on bladder afferent mechanisms.
To elucidate signaling pathways for afferent information generation and transmission.

Main Methods:

Systematic literature review of PubMed.
Focused on research published in the last 5 years up to June 2009.

Main Results:

Identified two primary signaling pathways: urothelial and myogenic.
The urothelial pathway involves urothelium, interstitial cells, and afferent nerves.
The myogenic pathway involves mechanoreceptors and myocyte contractile activity.

Conclusions:

Further understanding of all micturition control components is necessary.
Central nervous system processing of afferent information is crucial for controlling dysfunctional micturition.