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Published on: June 8, 2022
Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis
Ruth Dobson1, R F Miller, H E Palmer
1Neuroimmunology Unit, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, United Kingdom. ruth.dobson@qmul.ac.uk
Background:
Plasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine.
Objective:
To confirm that demyelinating diseases (DD) cause increased urinary FLCs.
Method:
Urinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC).
Result:
Subjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p<0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI.
Conclusions:
Urinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity.
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