Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A molecular understanding of magnesium aluminium silicate - drug, drug - polymer, magnesium aluminium silicate - polymer nanocomposite complex interactions in modulating drug release: Towards zero order release.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2020
Same author

Real time calorimetric characterisation of clay - drug complex dispersions and particles.

International journal of pharmaceutics: X·2019
Same author

Investigation of the intrinsic permeability of ice-templated collagen scaffolds as a function of their structural and mechanical properties.

Acta biomaterialia·2018
Same author

Collagen: a network for regenerative medicine.

Journal of materials chemistry. B·2016
Same author

Detection of phthalate esters as contaminants of lipid extracts from soil samples stored in standard soil bags.

Lipids·2016
Same author

Structural determinants of hydration, mechanics and fluid flow in freeze-dried collagen scaffolds.

Acta biomaterialia·2016

Related Experiment Video

Updated: Jun 16, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

Synchrotron X-ray microtomographic study of tablet swelling.

P R Laity1, R E Cameron

  • 1Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UK. prl28@cam.ac.uk

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|February 23, 2010
PubMed
Summary

Tablet swelling behavior varies significantly with excipient type, such as hydroxypropyl-methyl-cellulose (HPMC) and microcrystalline cellulose (MCC). Axial expansion, driven by hydration and stress relaxation, dominates tablet swelling, influenced by bubble formation within expansion zones.

More Related Videos

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
11:48

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

Published on: April 24, 2018

Related Experiment Videos

Last Updated: Jun 16, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Published on: July 4, 2014

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages
08:46

Using Synchrotron Radiation Microtomography to Investigate Multi-scale Three-dimensional Microelectronic Packages

Published on: April 13, 2016

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography
11:48

Microfluidic Chips for In Situ Crystal X-ray Diffraction and In Situ Dynamic Light Scattering for Serial Crystallography

Published on: April 24, 2018

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Chemical Engineering

Background:

  • Tablet swelling is a critical factor influencing drug release and bioavailability.
  • Excipient selection and compaction conditions significantly impact tablet performance.
  • Understanding swelling mechanisms is crucial for optimizing tablet formulations.

Purpose of the Study:

  • To investigate tablet swelling behavior using X-ray microtomography (XmicroT).
  • To analyze the influence of different excipients (HPMC, MCC, PGS) and compaction on swelling.
  • To elucidate the mechanisms driving tablet expansion and disintegration.

Main Methods:

  • Utilized synchrotron X-ray microtomography (XmicroT) with glass microsphere tracers.
  • Prepared tablet specimens using combinations of HPMC, MCC, and pre-gelatinised starch (PGS).
  • Analyzed swelling behavior under varying excipient compositions and compaction conditions.

Main Results:

  • Observed significant differences in swelling behavior based on excipient type and compaction.
  • Identified a transition from gel-forming to rapid expansion/disintegration with >70% MCC.
  • Domination of axial expansion, particularly in HPMC/MCC formulations, linked to hydration and stress relaxation.
  • Observed bubble formation within 'expansion zones' affecting water ingress and diffusion kinetics.

Conclusions:

  • Axial expansion, initiated by hydration and stress relaxation, is a key tablet swelling mechanism.
  • Excipient type and compaction critically influence swelling dynamics and disintegration.
  • Bubble formation within expansion zones can alter water penetration and drug release kinetics.