Activity of urethane in rat and mouse micronucleus tests after oral administration
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C Westmoreland1, M Plumstead, D Gatehouse
1Genetic and Reproductive Toxicology Department, Glaxo Group Research Ltd., Ware, Hert, Great Britain.
Mutation Research
|April 1, 1991
Abstract:
Urethane is readily detectable as an in vivo clastogen in the micronucleus test after oral administration to both rats and mice. Mice appear to be the more sensitive species. Positive results were obtained irrespective of the strain (CD1, CRH) or dosing regimen (single, triple-dose) used.