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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jun 16, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
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Citrulline evaluation in bowel transplantation.

P Ruiz1, P Tryphonopoulos, E Island

  • 1Department of Surgery, University of Miami School of Medicine, Miami, Florida, USA. pruiz@med.miami.edu

Transplantation Proceedings
|February 23, 2010
PubMed
Summary

Plasma citrulline levels significantly decrease during intestinal transplant rejection episodes. Monitoring citrulline may help detect graft rejection early.

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Last Updated: Jun 16, 2026

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
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Published on: November 6, 2012

Area of Science:

  • Transplantation immunology
  • Gastroenterology
  • Biomarker research

Background:

  • Intestinal transplantation is a complex procedure with a risk of graft rejection.
  • Early detection of rejection is crucial for patient outcomes.
  • Plasma citrulline is a potential biomarker for intestinal health.

Purpose of the Study:

  • To evaluate the correlation between plasma citrulline levels and rejection episodes in intestinal transplant recipients.
  • To determine if citrulline can serve as a predictive marker for graft rejection.

Main Methods:

  • Retrospective analysis of 5195 citrulline assays from intestinal transplant patients.
  • Correlation of citrulline levels with graft rejection status, defined by biopsy.
  • Comparison of citrulline levels across different rejection severities.

Main Results:

  • Average serum citrulline levels decreased significantly with increasing rejection severity.
  • Citrulline levels were 17.38 microm/L (no rejection), 13.05 microm/L (mild), 7.98 microm/L (moderate), and 6.05 microm/L (severe).
  • Further research is ongoing to assess citrulline's predictive power in conjunction with other biomarkers.

Conclusions:

  • Plasma citrulline levels show a significant correlation with intestinal graft rejection status.
  • Serial monitoring of citrulline may serve as an early warning for increased alloreactivity and potential rejection episodes.
  • Citrulline holds promise as a non-invasive biomarker for monitoring intestinal transplant recipients.