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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Related Experiment Video

Updated: Jun 16, 2026

Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection
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Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection

Published on: January 8, 2020

[Carbapenemases in Pseudomonas spp].

Carlos Juan Nicolau1, Antonio Oliver

  • 1Hospital Son Dureta, Universitat de les Illes Balears, Institut Universitari d' Investigació en Ciències de la Salut, Palma de Mallorca, España. carlos.juan@ssib.es <carlos.juan@ssib.es>

Enfermedades Infecciosas Y Microbiologia Clinica
|February 23, 2010
PubMed
Summary
This summary is machine-generated.

Pseudomonas aeruginosa is a major cause of hospital infections and antibiotic resistance. This review details carbapenemase enzymes in Pseudomonas, highlighting the threat of multidrug-resistant strains and the need for control strategies.

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Last Updated: Jun 16, 2026

Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection
08:34

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Published on: January 8, 2020

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
11:35

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants

Published on: May 4, 2018

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Pseudomonas aeruginosa is a significant nosocomial pathogen causing chronic respiratory infections.
  • High intrinsic and acquired antibiotic resistance poses a major threat to antimicrobial therapy.
  • Increasing detection of multiple antimicrobial resistance determinants, especially carbapenemases, is concerning.

Purpose of the Study:

  • To review the epidemiology, impact, and detection of carbapenemases in Pseudomonas species.
  • To highlight the threat posed by carbapenemase-producing P. aeruginosa and other Pseudomonas species.
  • To emphasize the need for multidisciplinary strategies to control these resistant strains.

Main Methods:

  • Literature review of carbapenemases in Pseudomonas spp.
  • Analysis of carbapenemase types (Class A, B, D) and their prevalence.
  • Discussion of epidemiology, impact, and detection methods.

Main Results:

  • Class B metallo-beta-lactamases (MBLs) like IMP and VIM are most relevant in Pseudomonas.
  • Class A (GES, KPC) and Class D (OXA) beta-lactamases are also detected.
  • Transferable carbapenemases are found in P. aeruginosa and other Pseudomonas species, acting as reservoirs.

Conclusions:

  • Carbapenemases in Pseudomonas spp. represent a significant global health threat.
  • Effective detection and control strategies are crucial to minimize the dissemination of multidrug-resistant strains.
  • Multidisciplinary approaches are needed to combat the spread of carbapenemase-producing P. aeruginosa.