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Updated: Jun 16, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Cervical remodeling during pregnancy and parturition

Brenda Timmons1, Meredith Akins, Mala Mahendroo

  • 1Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9032, USA.

Trends in Endocrinology and Metabolism: TEM
|February 23, 2010
PubMed

Appropriate and timely cervical remodeling is key for successful birth. Premature cervical opening can result in preterm birth which occurs in 12.5% of pregnancies. Research focused on the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. This review highlights recent findings that better define molecular processes driving progressive disorganization of the cervical extracellular matrix. This includes studies that redefine the role of immune cells and identify diverse functions of the cervical epithelia and hyaluronan in remodeling. New investigations proposing that infection-induced premature cervical remodeling is distinct from the normal process are presented. Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models.

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