Related Experiment Video
Updated: Jun 16, 2026

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Published on: March 12, 2019
Investigation of biokinetics of radioiodine with a population kinetics approach
T Janzen1, A Giussani, C Canzi
1Institute of Radiation Protection, Helmholtz Zentrum München, Ingolstädter Landstr 1, 85764 Neuherberg, Germany. tilman.janzen@helmholtz-muenchen.de
Abstract:
The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.
Related Concept Videos
Measurement of Bioavailability: Pharmacokinetic Methods
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Measurement of Bioavailability: Pharmacodynamic Methods
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Bioavailability Study Design: Single Versus Multiple Dose Studies
Bioavailability Study Design: Healthy Subjects Versus Patients
