Related Experiment Video
Updated: Jun 16, 2026
05:55
Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
Published on: September 27, 2024
TNF and bone
Jean-Pierre David1, Georg Schett
1Rheumatology and Immunology, Department of Internal Medicine 3, University of Erlangen-Nuremberg, Krankenhausstrasse 12, Erlangen, Germany. jean-pierre.david@uk-erlangen.de
Current Directions in Autoimmunity
|February 23, 2010
Summary
Bone remodeling is vital for growth, maintenance, and repair throughout life. Disturbances cause diseases like osteoporosis, and this chapter explores the role of Tumor Necrosis Factor-alpha (TNF-alpha) in bone remodeling.
Area of Science:
- Bone biology and remodeling processes.
- Pathophysiology of bone diseases.
- Immunology and inflammatory signaling in bone.
Background:
- Bone undergoes continuous remodeling for development, maintenance, and repair.
- Disruptions in bone remodeling lead to pathologies like osteoporosis and inflammatory bone loss.
- Tumor Necrosis Factor-alpha (TNF-alpha) is implicated in various bone pathologies.
Purpose of the Study:
- To present and discuss the role of TNF-alpha in mediating bone remodeling.
- To highlight the connection between TNF-alpha and common bone pathologies.
Main Methods:
- Review of existing literature on bone remodeling and TNF-alpha.
- Analysis of the mechanisms by which TNF-alpha influences bone cells.
- Discussion of clinical implications in diseases like rheumatoid arthritis.
Main Results:
- TNF-alpha plays a significant role in regulating bone remodeling processes.
- Dysregulation of TNF-alpha contributes to bone loss in inflammatory conditions.
- Understanding TNF-alpha's role is crucial for therapeutic strategies.
Conclusions:
- TNF-alpha is a key mediator in bone remodeling.
- Targeting TNF-alpha may offer therapeutic benefits for bone diseases.
- Further research is needed to fully elucidate TNF-alpha's complex role in bone health.
![Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58491.jpg&w=3840&q=50)
Related Concept Videos
01:30Bone Cells and Tissue
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:29Bone Formation by Intramembranous Ossification
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
01:10Bones of the Lower Limb: Tibia and Fibula
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
01:18The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...