Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone as Supporting Connective Tissue

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

Bone Formation by Intramembranous Ossification

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

Bones of the Lower Limb: Tibia and Fibula

Bones of the Lower Limb: Tibia and Fibula

The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A model of chronic enthesitis and new bone formation characterized by multimodal imaging.

Disease models & mechanisms·2018

Same author

A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin.

Bone·2018

Same author

Effects of ustekinumab versus tumor necrosis factor inhibition on enthesitis: Results from the enthesial clearance in psoriatic arthritis (ECLIPSA) study.

Seminars in arthritis and rheumatism·2018

Same author

Therapeutic benefit of apremilast on enthesitis and dactylitis in patients with psoriatic arthritis: a pooled analysis of the PALACE 1-3 studies.

RMD open·2018

Same author

Physiological effects of modulating the interleukin-6 axis.

Rheumatology (Oxford, England)·2018

Same author

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.

Cell reports·2018

Same journal

The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions.

Current directions in autoimmunity·2010

Same journal

TNF in host resistance to tuberculosis infection.

Current directions in autoimmunity·2010

Same journal

TNF-alpha and obesity.

Current directions in autoimmunity·2010

Same journal

TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.

Current directions in autoimmunity·2010

Same journal

T cells as sources and targets of TNF: implications for immunity and autoimmunity.

Current directions in autoimmunity·2010

Same journal

Type I interferon: a new player in TNF signaling.

Current directions in autoimmunity·2010

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

TNF and bone.

Jean-Pierre David¹, Georg Schett

¹Rheumatology and Immunology, Department of Internal Medicine 3, University of Erlangen-Nuremberg, Krankenhausstrasse 12, Erlangen, Germany. jean-pierre.david@uk-erlangen.de

Current Directions in Autoimmunity

|February 23, 2010

Summary

This summary is machine-generated.

Bone remodeling is vital for growth, maintenance, and repair throughout life. Disturbances cause diseases like osteoporosis, and this chapter explores the role of Tumor Necrosis Factor-alpha (TNF-alpha) in bone remodeling.

More Related Videos

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [¹⁸F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Quantitative [¹⁸F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

Published on: August 8, 2019

Area of Science:

Bone biology and remodeling processes.
Pathophysiology of bone diseases.
Immunology and inflammatory signaling in bone.

Background:

Bone undergoes continuous remodeling for development, maintenance, and repair.
Disruptions in bone remodeling lead to pathologies like osteoporosis and inflammatory bone loss.
Tumor Necrosis Factor-alpha (TNF-alpha) is implicated in various bone pathologies.

Purpose of the Study:

To present and discuss the role of TNF-alpha in mediating bone remodeling.
To highlight the connection between TNF-alpha and common bone pathologies.

Main Methods:

Review of existing literature on bone remodeling and TNF-alpha.
Analysis of the mechanisms by which TNF-alpha influences bone cells.
Discussion of clinical implications in diseases like rheumatoid arthritis.

Main Results:

TNF-alpha plays a significant role in regulating bone remodeling processes.
Dysregulation of TNF-alpha contributes to bone loss in inflammatory conditions.
Understanding TNF-alpha's role is crucial for therapeutic strategies.

Conclusions:

TNF-alpha is a key mediator in bone remodeling.
Targeting TNF-alpha may offer therapeutic benefits for bone diseases.
Further research is needed to fully elucidate TNF-alpha's complex role in bone health.