Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
Ainhoa Etxeberria1, Jean-Marie Mangin1, Adan Aguirre1
1Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
Nature Neuroscience
|February 23, 2010
Abstract:
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.


