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Related Experiment Video

Updated: Jun 16, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Quantitative cerebral blood flow with optical coherence tomography.

Vivek J Srinivasan1, Sava Sakadzić, Iwona Gorczynska

  • 1Photon Migration Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA. vjsriniv@nmr.mgh.harvard.edu

Optics Express
|February 23, 2010
PubMed
Summary

Researchers developed a new method using Doppler Optical Coherence Tomography for precise, high-resolution measurement of cerebral blood flow (CBF) in rats. This technique offers a reliable way to monitor brain blood flow longitudinally in animal models.

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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Published on: May 27, 2020

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Last Updated: Jun 16, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Absolute measurements of cerebral blood flow (CBF) are crucial for understanding brain pathophysiology.
  • Existing methods lack high resolution and longitudinal monitoring capabilities in small animal models like rats and mice.

Purpose of the Study:

  • To develop and validate a novel method for in vivo, high-resolution, regional CBF measurements in the rat cortex.
  • To establish a technique for longitudinal monitoring of CBF in animal models.

Main Methods:

  • Utilized three-dimensional Doppler Optical Coherence Tomography (OCT) with cranial window preparations.
  • Developed a quantitative statistical model to account for static tissue effects on velocity sensitivity.
  • Introduced an absolute flow calculation method independent of vessel angle knowledge.

Main Results:

  • Presented methods and algorithms for sensitive 3D flow measurements and angiography of the rat cortex.
  • Demonstrated that OCT-derived absolute CBF values in rats align with previous autoradiography measures.
  • Validated the capability of Doppler OCT for absolute flow quantification in animal models.

Conclusions:

  • Doppler OCT provides a viable, high-resolution method for absolute CBF measurements in rats.
  • This technique enables longitudinal monitoring of cerebral blood flow in small animal research.
  • The developed methods advance the study of cerebral pathophysiology in animal models.