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Related Experiment Videos

Dopamine sensitivity in rats selectively bred for increases in cholinergic function.

A D Crocker1, D H Overstreet

  • 1Department of Clinical Pharmacology, School of Medicine, Flinders University of South Australia, Bedford Park, Australia.

Pharmacology, Biochemistry, and Behavior
|January 1, 1991
PubMed
Summary
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Flinders Sensitive Line rats show altered dopamine sensitivity, being more sensitive to some effects and less to others. These behavioral changes occur without alterations in dopamine receptor levels.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Cholinergic and dopaminergic systems are known to interact extensively.
  • Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats are selectively bred for distinct cholinergic functions.

Purpose of the Study:

  • To investigate potential differences in dopamine sensitivity between FSL and FRL rats.
  • To explore the relationship between cholinergic function and dopamine system responsivity.

Main Methods:

  • Administered dopamine agonists and antagonists to FSL and FRL rats.
  • Assessed behavioral responses including hypothermia, stereotypy, and catalepsy.
  • Measured dopamine receptor concentrations using binding techniques and autoradiography.

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Main Results:

  • FSL rats exhibited supersensitivity to the hypothermic effects of dopamine agonists.
  • FSL rats showed subsensitivity to the stereotypy-inducing effects of dopamine agonists.
  • No significant differences in dopamine receptor concentrations were found between FSL and FRL rats.
  • Dopamine antagonists suggested FSL rats might be more sensitive to catalepsy induction.

Conclusions:

  • Dopamine sensitivity changes associated with cholinergic alterations are function-dependent.
  • These behavioral modifications in dopamine sensitivity are not linked to changes in dopamine receptor density.