Related Experiment Video
Updated: Jun 16, 2026
10:40
Analysis of Cap-binding Proteins in Human Cells Exposed to Physiological Oxygen Conditions
Published on: December 28, 2016
A mini review of MAR-binding proteins
Tian-Yun Wang1, Zhong-Min Han, Yu-Rong Chai
1Department of Biochemistry and Molecular Biology, Xinxiang Medical University, Jinsui Road, Xinxiang, Henan, 453003, People's Republic of China. wtianyuncn@126.com
Molecular Biology Reports
|February 23, 2010
Summary
Matrix attachment regions (MARs) and their binding proteins (MARBPs) are crucial for DNA organization and gene regulation. This review highlights recent advances in understanding MARBPs roles in enhancing transgene expression and cellular processes.
Area of Science:
- Genomics
- Molecular Biology
- Biochemistry
Background:
- Genomic DNA is organized into loop domains anchored by matrix attachment regions (MARs).
- MARs interact with MAR binding proteins (MARBPs) to regulate gene expression and DNA replication.
- MARBPs are involved in various cellular processes, including chromosome folding and apoptosis.
Purpose of the Study:
- To review recent advances in the understanding of MAR binding proteins (MARBPs).
- To highlight the regulatory roles of MARBPs in gene expression and DNA organization.
Main Methods:
- Literature review of recent research on MARBPs.
- Analysis of identified MARBPs across different species (humans, plants, animals, algae).
Main Results:
- MARBPs play a key role in enhancing transgene expression and reducing expression variability.
- MARBPs are integral components of co-regulator complexes involved in gene expression.
- MARBPs are implicated in fundamental cellular processes such as chromosome folding, cell development, and apoptosis.
Conclusions:
- MARBPs are essential regulators of genome organization and gene expression.
- Continued research on MARBPs will further elucidate their complex roles in cellular functions and potentially in therapeutic applications.
Related Concept Videos
01:39Mitochondrial Precursor Proteins
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70 chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial precursors...
Most of the mitochondrial precursors...
01:58Cooperative Allosteric Transitions
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
01:42Microtubule Associated Proteins (MAPs)
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
02:13Cooperative Binding of Transcription Regulators
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
02:13Cooperative Binding of Transcription Regulators
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form dimers that...
02:21Globular and Fibrous Proteins
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...