Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Panic attack frequency and vulnerability to anxiogenic challenge studies.

S D Targum1

  • 1Department of Psychiatry, Crozer-Chester Medical Center, Upland, PA 19013.

Psychiatry Research
|January 1, 1991
PubMed
Summary

Patients with panic disorder (PD) experience greater anxiety from lactate and fenfluramine challenges. Recent panic attack frequency, not underlying traits, predicts heightened anxiety responses to these stimuli.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparability of blinded remote and site-based assessments of response to adjunctive esketamine or placebo nasal spray in patients with treatment resistant depression.

Journal of psychiatric research·2019
Same author

New Rx for psychoses in Alzheimer's, Parkinson's.

Contemporary longterm care·2001
Same author

Efficacy of quetiapine in Parkinson's patients with psychosis.

Journal of clinical psychopharmacology·2000
Same author

Psychoses in the elderly: a spectrum of disorders.

The Journal of clinical psychiatry·1999
Same author

A 24-week randomized trial of controlled-release physostigmine in patients with Alzheimer's disease.

Neurology·1999
Same author

A double-blind, placebo-controlled trial of nefazodone in the treatment of patients hospitalized for major depression.

The Journal of clinical psychiatry·1998

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Panic disorder (PD) is characterized by recurrent, spontaneous panic attacks.
  • The factors influencing anxiety responses to provocative stimuli in PD are not fully understood.
  • Previous research suggests both trait and state factors may contribute to anxiety.

Purpose of the Study:

  • To investigate the influence of recent panic attack frequency on anxiety responses to pharmacological challenges in patients with panic disorder.
  • To differentiate the roles of trait versus state anxiety in experimentally induced anxiety reactions.

Main Methods:

  • Administered intravenous lactate infusion and oral fenfluramine challenges to 26 PD patients and 12 controls.
  • Assessed anxiety responses to challenges.

Related Experiment Videos

  • Correlated panic attack frequency with anxiety response severity.

    • Main Results:

    • PD patients exhibited significantly greater anxiety responses to both lactate and fenfluramine compared to controls.
    • Higher frequency of recent spontaneous panic attacks correlated with increased anxiogenic responses.
    • 75% of high-frequency PD patients (≥1 attack/week) responded to both challenges, versus 0% of low-frequency patients (≤1 attack/month).

    Conclusions:

    • The current heightened anticipatory state, influenced by recent panic attacks, predominantly drives experimentally induced anxiety in PD.
    • Trait factors appear less influential than state factors in acute anxiety provocation.
    • Future research should account for recent panic attack frequency when assessing reactivity to provocative stimuli.