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Related Experiment Video

Updated: Jun 16, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Cellular functions of menin.

Geoffrey N Hendy¹, Hiroshi Kaji, Lucie Canaff

¹Calcium Research Laboratory, Rm. H4.67, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada. geoffrey.hendy@mcgill.ca

Advances in Experimental Medicine and Biology

|February 24, 2010

Summary

This summary is machine-generated.

Menin protein

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Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

Menin, a protein discovered 10 years ago, has numerous identified cellular functions.
Its specific role in tumor suppression remains unclear.
Menin is primarily located in the nucleus and functions as a scaffold protein.

Purpose of the Study:

To elucidate the specific functions of menin related to its tumor suppressor role.
To understand how menin regulates gene transcription and chromatin remodeling.
To clarify menin's involvement in cell cycle control and differentiation.

Main Methods:

Investigating menin's interaction with histone deacetylase and methyltransferase activities.
Analyzing menin's regulation of cell cycle kinase inhibitor and homeobox domain genes.
Examining menin's facilitation of TGF-beta signaling pathways via Smad proteins.

Main Results:

Menin regulates gene transcription through chromatin remodeling, involving histone deacetylase and methyltransferase activities.
It controls the expression of key genes, including cell cycle kinase inhibitors and homeobox genes.
Menin enhances the transcriptional activity of Smad proteins, crucial for TGF-beta signaling.

Conclusions:

Menin plays a significant role in regulating gene expression and chromatin structure.
Its functions are linked to cell cycle control and differentiation processes.
Menin's tumor suppressor activity is mediated through its transcriptional regulatory functions.