Related Experiment Video

Updated: Jun 16, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Ascending aortic pressure-derived indices are associated with the presence and severity of aortic stenosis

Serkan Cay1, Goksel Cagirci, Ramazan Atak

  • 1Department of Cardiology, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey. cayserkan@yahoo.com

Blood Pressure
|February 24, 2010
PubMed

Insights

Ascending aortic pressure indices, including fractional pulse pressure (FPP) and pulsatility index (PI), are linked to calcific aortic stenosis (AS). Higher FPP and PI levels increase AS risk, suggesting blood pressure

Area of Science:

  • Cardiovascular Medicine
  • Hemodynamics
  • Aortic Stenosis Pathophysiology

Background:

  • Atherosclerosis and calcific aortic stenosis (AS) share similar pathophysiological mechanisms.
  • Investigating the link between ascending aortic pressure indices and AS hemodynamics is crucial.

Purpose of the Study:

  • To examine the association between ascending aortic pressure-derived indices and hemodynamic characteristics in calcific AS.
  • To determine if blood pressure plays a role in AS pathogenesis.

Main Methods:

  • A study of 90 patients (26 males, 64 females; mean age 64.4 years) with AS and a control group.
  • Ascending aortic pressure-derived indices were measured via catheterization in both groups.
  • Groups were matched for demographic characteristics.

Main Results:

  • Aortic fractional pulse pressure (FPP) and pulsatility index (PI) were significantly higher in patients with AS.
  • Mean aortic gradient correlated positively with aortic diastolic pressure, FPP, and PI.
  • Elevated FPP and PI levels were independently associated with increased risk of AS.

Conclusions:

  • Ascending aortic pressure-derived indices are significantly associated with the presence and severity of calcific AS.
  • These findings confirm the involvement of blood pressure in the pathogenesis of AS.
Abstract

More Related Videos

A Minimally Invasive Model of Aortic Stenosis in Swine06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...