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Updated: Jun 16, 2026

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
Intraosseous soft tissue perineurioma: report of a vertebral example
A Sav1, B W Scheithauer, W A S Taylor
1Department of Pathology, Acibadem Medical Center, Istanbul, Turkey.
Objective:
To describe a unique intraosseous perineurioma affecting the L2 vertebral body and pedicle of a 28-year-old female.
Material:
A lytic, expansive lesion virtually limited to bone was gross totally excised; only minimal epidural extension was noted.
Methods:
Histologic, immunohistochemical and ultrastructural studies were performed.
Results:
The tumor was partially encapsulated, moderately cellular, and showed classic features of benign soft tissue perineurioma, being composed of interlacing fascicles of spindle cells with undulating nuclei and long, very narrow, cytoplasmic processes. Immunohistochemistry showed reactivity for EMA, Glut-1, claudin, collagen-4 and CD34; no S-100 or neurofilament protein staining was seen to suggest an origin in nerve.
Conclusion:
Perineurioma, a tumor affecting soft tissue, and presumably nerve-unassociated, may affect bone. No prior entirely osseous examples have been reported. This tumor expands the differential diagnosis of spindle cell tumors of bone.
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