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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Video

Updated: Jun 16, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Asthma: clinical expression and molecular mechanisms.

Robert F Lemanske1, William W Busse

  • 1Department of Pediatrics, University of Wisconsin Medical School, Madison, Wis., USA. rfl@medicine.wisc.edu

The Journal of Allergy and Clinical Immunology
|February 24, 2010
PubMed
Summary

Asthma is a complex respiratory condition with varied symptoms and causes. While treatments help manage asthma, severe exacerbations remain a significant health concern, necessitating ongoing research into its pathophysiology and treatment.

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Murine Model of Allergen Induced Asthma
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Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Immunology

Background:

  • Asthma is a heterogeneous respiratory disease with variable clinical presentations.
  • Diagnosis relies on clinical assessment of symptoms and response to therapy due to lack of definitive biomarkers.
  • Despite current treatments, severe asthma exacerbations contribute significantly to morbidity and mortality.

Purpose of the Study:

  • To review the key clinical features of asthma.
  • To highlight recent advancements in understanding asthma pathophysiology.
  • To discuss current and emerging treatment strategies for asthma.

Main Methods:

  • Literature review of clinical features, pathophysiology, and treatment of asthma.
  • Emphasis on heterogeneity and variability in asthma presentation.
  • Focus on recent scientific advances in the field.

Main Results:

  • Asthma exhibits significant heterogeneity influenced by genetic and environmental factors.
  • Clinical diagnosis is based on symptom patterns and reversibility of airflow obstruction.
  • Acute exacerbations remain a major challenge in asthma management across all age groups.

Conclusions:

  • Asthma management requires understanding its complex and heterogeneous nature.
  • Continued research into pathophysiology is crucial for developing more effective treatments.
  • Addressing severe exacerbations is key to reducing asthma-related morbidity and mortality.