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Treatment of systemic sporotrichosis with ketoconazole

D L Calhoun1, H Waskin, M P White

  • 1Medical Service, Veterans Affairs Medical Center, Tucson, Arizona 85723.

Reviews of Infectious Diseases
|January 1, 1991
PubMed

Insights

Ketoconazole offers a well-tolerated oral treatment for deep Sporothrix schenckii infections. This antifungal agent demonstrated significant efficacy in resolving deep-seated sporotrichosis, including joint and systemic cases.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Deep soft tissue infections caused by Sporothrix schenckii are rare in humans.
  • Traditional therapies for sporotrichosis often involve toxic medications.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of ketoconazole in treating deep-seated sporotrichosis.
  • To assess long-term outcomes and remission rates following ketoconazole therapy.

Main Methods:

  • Retrospective case series of 11 patients with deep-seated sporotrichosis treated with oral ketoconazole.
  • Dosage ranged from 400-800 mg daily, with treatment duration varying.
  • Outcomes assessed included resolution of infection and sustained remission post-treatment.

Main Results:

  • Eight of eleven patients showed complete resolution of infection during ketoconazole therapy.
  • Six patients achieved sustained remission for 6 months to 5 years after treatment cessation.
  • One additional patient remained in remission 4 years after starting ketoconazole.

Conclusions:

  • Oral ketoconazole is a well-tolerated and effective treatment option for deep-seated sporotrichosis.
  • Prolonged treatment with ketoconazole (400-800 mg daily) is associated with durable responses.
  • Ketoconazole may be a beneficial alternative for patients with systemic sporotrichosis.

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