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A program of outpatient parenteral antibiotic therapy for serious pediatric bacterial infections

R Dagan1, M Einhorn

  • 1Pediatric Infectious Disease Unit, Soroka Medical Center, Beer Sheva, Israel.

Reviews of Infectious Diseases
|January 1, 1991
PubMed

Insights

Outpatient parenteral antibiotic therapy (OPAT) for pediatric serious bacterial infections achieved a 98.5% cure rate. This program significantly reduced hospital stays, saving 1,334 days for 140 children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Serious bacterial infections in children often require prolonged hospitalization.
  • Outpatient parenteral antibiotic therapy (OPAT) presents a potential alternative to inpatient care.
  • Establishing effective OPAT programs requires careful patient selection and logistical support.

Purpose of the Study:

  • To evaluate the efficacy and impact of an established pediatric OPAT program.
  • To assess the feasibility and outcomes of treating serious pediatric bacterial infections via OPAT.
  • To determine the resource utilization and cost-effectiveness of the OPAT program.

Main Methods:

  • Implementation of a pediatric OPAT program at Soroka University Medical Center.
  • Inclusion criteria: suitable infection, available antibiotic (ceftriaxone IM), informed parents, 24/7 home-hospital communication and transport.
  • Data collection on cure rates, hospital days saved, and patient numbers over 17 months.

Main Results:

  • The OPAT program achieved a high cure rate of 98.5%.
  • Significant reduction in hospital resource utilization, with an estimated 1,334 hospital days saved.
  • The program successfully managed 140 pediatric patients over a 17-month period.

Conclusions:

  • Pediatric OPAT, utilizing ceftriaxone, is a highly effective treatment strategy for serious bacterial infections.
  • OPAT offers substantial benefits in reducing hospital length of stay and associated healthcare costs.
  • The program demonstrates the viability of transitioning pediatric care from inpatient to outpatient settings under specific conditions.

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