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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

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Related Experiment Video

Updated: Jun 16, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-density lipoprotein and the acute phase response.

Anisa Jahangiri1

  • 1Division of Endocrinology, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA. anisa.jahangiri@uky.edu

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 24, 2010
PubMed
Summary

Inflammation impairs high-density lipoprotein (HDL) function by altering its remodeling proteins and reducing cholesterol efflux capacity. ATP-binding-membrane-cassette transporters play a protective role by reducing inflammation signaling.

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High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiovascular Research

Background:

  • Inflammation significantly alters lipoprotein profiles, especially high-density lipoprotein (HDL).
  • HDL's anti-inflammatory properties are diminished during inflammatory states.
  • Understanding HDL remodeling during inflammation is crucial for cardiovascular health.

Purpose of the Study:

  • To review HDL remodeling proteins and lipases and their changes during inflammation.
  • To discuss the impact of altered HDL remodeling on HDL function.
  • To examine the role of ATP-binding-membrane-cassette transporters in HDL's protective actions.

Main Methods:

  • Review of studies on HDL remodeling in vitro and in vivo.
  • Analysis of HDL composition and cholesterol efflux capacity in humans during acute phase response.
  • Examination of ATP-binding-membrane-cassette transporter A1 and G1 knockout mouse models.

Main Results:

  • Remodeling of acute phase HDL generates particles capable of cholesterol efflux.
  • Human studies showed reduced HDL phospholipids and impaired cholesterol efflux capacity during inflammation.
  • Knockout mouse studies revealed anti-inflammatory roles for ATP-binding-membrane-cassette transporters in reducing free cholesterol and lipid rafts.

Conclusions:

  • Acute phase HDL contains serum amyloid A, which can be released during remodeling.
  • HDL's ability to promote cholesterol efflux is key to its protective effects during inflammation.
  • ATP-binding-membrane-cassette transporters contribute to HDL's anti-inflammatory actions by modulating cell membrane cholesterol.