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Updated: Jun 15, 2026

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum

Francesco Ricci1, Gianluca Adornetto, Danila Moscone

  • 1University of Rome Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Via della Ricerca Scientifica, 00133, Rome, Italy.

Chemical Communications (Cambridge, England)
|February 24, 2010
PubMed

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Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.