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Updated: Jun 15, 2026
10:13
Transplantation of Bioengineered Lung Using Decellularized Mouse Lungs and Primary Human Endothelial Cells
Published on: March 28, 2025
Advances in artificial lungs.
1Department of Emergency and General Medicine, Koshimizu Red Cross Hospital, Shari-gun, Hokkaido, Japan. ZUB07316@nifty.com
Summary
Artificial lungs are advancing for extended use in extracorporeal membrane oxygenation (ECMO) and as bridges to lung transplantation. Research focuses on improving durability and antithrombogenicity for long-term patient support.
Area of Science:
- Biomedical Engineering
- Cardiovascular Surgery
- Respiratory Medicine
Background:
- Artificial lungs are established for extracorporeal circulation during open-heart surgery, offering adequate gas exchange and antithrombogenicity.
- Increasing use of artificial lungs for long-term extracorporeal membrane oxygenation (ECMO) in critical respiratory/circulatory failure cases.
- Current commercial artificial lungs meet immediate needs but require enhanced durability for prolonged support.
Purpose of the Study:
- To review recent advancements in artificial lung technology.
- To discuss current trends in research and development for artificial lungs.
- To highlight the evolving applications of artificial lungs in critical care and transplantation.
Main Methods:
- Review of current literature on artificial lung technology and applications.
- Analysis of research trends focusing on material science, device design, and clinical outcomes.
- Examination of innovations aimed at improving device longevity and biocompatibility.
Main Results:
- Significant growth in the application of artificial lungs for long-term ECMO.
- Developmental focus on enhancing durability and antithrombogenicity for weeks or months of use.
- Emerging research into artificial lungs as a bridge to lung transplantation and as implantable devices.
Conclusions:
- Artificial lungs are crucial for managing severe respiratory and circulatory failure.
- Future developments aim for extended functionality, supporting critical patients for longer durations.
- The field is progressing towards advanced applications like transplantation support and fully implantable solutions.
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