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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Stromal Cell Isolation From Hematopoietic Organs
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Published on: January 26, 2024

International stem cell registries.

Joeri Borstlap1, Mai X Luong, Heather M Rooke

  • 1Berlin-Brandenburg Center for Regenerative Therapies, CellNet Group, Berlin, Germany.

In Vitro Cellular & Developmental Biology. Animal
|February 24, 2010
PubMed
Summary
This summary is machine-generated.

This review examines three major stem cell registries, detailing their unique features and mandates. It explores challenges and opportunities for collaboration to improve information exchange for human embryonic stem (hES) and induced pluripotent stem (iPS) cell lines.

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Hundreds of human embryonic stem (hES) cell lines have been derived globally.
  • New technologies for producing pluripotent stem cells have emerged.
  • Stem cell registries are crucial for organizing and disseminating cell line information.

Purpose of the Study:

  • To review the current state of major stem cell registries.
  • To compare the unique qualities and mandates of three key registries.
  • To discuss prospects for collaboration among registries.

Main Methods:

  • Overview of the European hES Cell Registry.
  • Description of the Registry of hES Cell Line Provenance (International Society for Stem Cell Research).
  • Examination of the International Stem Cell Registry of hES and induced pluripotent stem cell lines (University of Massachusetts Medical School).

Main Results:

  • Each registry possesses distinct mandates and features.
  • There is some overlap in the goals and information provided by the registries.
  • The review highlights the need for integrated approaches.

Conclusions:

  • Collaboration among stem cell registries is essential.
  • An integrated approach can minimize duplication of efforts.
  • Facilitating information exchange is key for the stem cell community.