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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

Molecular Factors Affecting Cell Division

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

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Related Experiment Video

Updated: Jun 7, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Circadian cell-cycle progression: Cracking open the gate.

Jörg Morf¹, Ueli Schibler

¹Department of Molecular Biology and NCCR Frontiers in Genetics, Geneva, Switzerland. joerg.morf@unige.ch

|February 25, 2010

Summary

This summary is machine-generated.

Cyanobacteria cell division is regulated by the circadian clock. Dong et al. identified key clock components controlling the midcell ring formation for cytokinesis.

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Last Updated: Jun 7, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

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Published on: September 27, 2012

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Published on: November 11, 2016

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Published on: September 26, 2025

Area of Science:

Microbiology
Cell Biology
Circadian Biology

Background:

Cyanobacteria exhibit a close relationship between cell division and their circadian rhythm.
Understanding the molecular mechanisms linking these two fundamental processes is crucial.

Discussion:

Dong et al. (2010) investigated the molecular players connecting the circadian clock to cell division machinery.
The study focuses on how circadian clock components influence the spatial organization of the cell division apparatus.

Key Insights:

Identification of specific circadian clock components that directly regulate the formation of the midcell ring.
Demonstration of a direct regulatory link between the circadian cycle and the initiation of cytokinesis in cyanobacteria.

Outlook:

Further research could explore how this linkage impacts overall cyanobacterial physiology and adaptation.
Investigating conserved mechanisms in other organisms may reveal broader biological significance.