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Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Data Validation01:03

Data Validation

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...

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Related Experiment Video

Updated: Jun 15, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Identification and validation of lupus nephritis cases using administrative data.

L B Chibnik1, E M Massarotti, K H Costenbader

  • 1Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. lchibnik@rics.bwh.harvard.edu

Lupus
|February 25, 2010
PubMed
Summary

Identifying patients with lupus nephritis for research is possible using Medicaid billing data. A strategy combining lupus and renal ICD-9 codes with nephrologist claims achieved 88% accuracy.

Related Experiment Videos

Last Updated: Jun 15, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Nephrology
  • Health Services Research
  • Medical Informatics

Background:

  • Large administrative databases like Medicaid claims are valuable for studying rare diseases such as lupus nephritis.
  • Accurate patient identification from claims data is crucial for reliable health services research.

Purpose of the Study:

  • To develop and validate an algorithm for identifying lupus nephritis cases using ICD-9 billing codes.
  • To assess the performance of different coding strategies for lupus nephritis case ascertainment.

Main Methods:

  • Compared four ICD-9 code-based strategies to identify lupus nephritis patients from Medicaid data (2000-2007).
  • Strategies involved combinations of Systemic Lupus Erythematosus (SLE) codes (ICD-9 710.0), renal ICD-9 codes, and nephrologist visits.
  • Validated algorithm performance using positive predictive value (PPV) through medical record review.

Main Results:

  • A total of 234 subjects were identified and their medical records reviewed.
  • The third strategy, utilizing a combination of lupus and renal ICD-9 codes plus nephrologist encounter claims, demonstrated the highest PPV.
  • This optimized strategy achieved an 88% positive predictive value for identifying lupus nephritis patients.

Conclusions:

  • A specific algorithm combining lupus and renal ICD-9 codes with nephrologist claims provides a high PPV for identifying lupus nephritis patients.
  • This method offers a reliable approach for health services research using administrative claims data.
  • The developed strategy can serve as a model for identifying patients with other rare diseases within large datasets.