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Marjolin ulcers arising on extremities.

Yigit Ozer Tiftikcioglu1, Cuneyt Ozek, Ufuk Bilkay

  • 1Division of Plastic and Reconstructive Surgery, Ege University Medical School, Izmir, Turkey. drtiftikcioglu@yahoo.com

Annals of Plastic Surgery
|February 25, 2010
PubMed
Summary
This summary is machine-generated.

Marjolin ulcers on extremities are aggressive epidermoid carcinomas. Tumor size and histologic grade significantly impact survival rates, emphasizing the need for adequate surgical intervention.

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Marjolin ulcer, an epidermoid carcinoma, exhibits high aggressiveness, particularly on extremities.
  • This aggressive nature necessitates prompt attention and extensive surgical management.

Purpose of the Study:

  • To retrospectively analyze the clinical characteristics, treatment outcomes, and prognostic factors of Marjolin ulcers on extremities.
  • To evaluate survival rates and identify key predictors of patient outcomes.

Main Methods:

  • Retrospective review of medical records for 62 patients with extremity Marjolin ulcers (arising from burn scars) followed for at least 5 years.
  • Analysis of treatment modalities including wide local excision, lymph node dissection, and amputation.
  • Statistical analysis of prognostic factors such as metastasis, histologic grade, and tumor size.

Main Results:

  • The mean age of patients was 48.0 years, with an average of 35.9 years between burn injury and carcinoma development.
  • Regional lymph node metastasis occurred in 40.3% of patients, and lung metastasis in 41.9%.
  • Tumor size and histologic grade were significant prognostic factors; 5-year survival rates were 42.9% (upper extremity) and 58.3% (lower extremity).

Conclusions:

  • Marjolin ulcers on extremities are aggressive malignancies requiring adequate surgical treatment.
  • Tumor size and histologic grade are crucial prognostic indicators, guiding treatment strategies and patient management.
  • The study underscores the importance of comprehensive surgical approaches and highlights metastasis as a critical factor influencing survival.