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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic
Brooke R Snyder1, Andrew M Chiu, Darwin J Prockop
1Yerkes National Primate Research Center, Atlanta, Georgia, United States of America.
Plos One
|February 25, 2010
Summary
Human multipotent stromal cells (hMSCs) implantation in Huntington disease (HD) mouse models stimulated neural stem cell growth and reduced brain atrophy. Further research is needed to optimize hMSC therapy for HD treatment.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Regenerative Medicine
Background:
- Human multipotent stromal cells (hMSCs) from bone marrow stimulate neural stem cell activity.
- Huntington disease (HD) is a neurodegenerative disorder.
- Previous studies showed hMSC neurogenic effects in the hippocampus.
Purpose of the Study:
- To investigate the therapeutic potential of hMSCs in a mouse model of Huntington disease (HD).
- To assess the effects of hMSC implantation on endogenous neural stem cells and striatal atrophy in HD mice.
Main Methods:
- hMSCs were implanted into the striatum of N171-82Q transgenic mice, a model for HD.
- Proliferation, migration, and differentiation of endogenous neural stem cells were evaluated.
- Neurotrophic signaling and striatal atrophy were assessed in treated HD mice.
Main Results:
- Implanted hMSCs were transient, disappearing within 3 to 15 days.
- hMSCs increased proliferation and neural differentiation of endogenous neural stem cells for up to 30 days.
- hMSC treatment enhanced neurotrophic signaling and reduced striatal atrophy in HD mice.
Conclusions:
- Neural implantation of hMSCs shows potential therapeutic benefits for Huntington disease.
- Optimization of dosage, treatment schedule, and administration route is required for clinical application.
