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Related Experiment Video

Updated: Jun 15, 2026

Experimental Approaches to Tissue Engineering
16:41

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Modular Tissue Engineering: Engineering Biological Tissues from the Bottom Up.

Jason W Nichol1, Ali Khademhosseini

  • 1Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139.

Soft Matter
|February 25, 2010
PubMed
Summary
This summary is machine-generated.

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Modular tissue engineering builds biological tissues from small, functional units. This "bottom-up" approach aims to create complex tissues with improved function by assembling engineered microtissues into larger structures.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Tissue engineering seeks to restore function to damaged or diseased tissues.
  • Creating complex, native-like tissue structures requires advanced fabrication techniques.
  • Mimicking intricate native tissue architecture, including microvasculature and specific morphology, is a key challenge.

Purpose of the Study:

  • To review the potential and limitations of "bottom-up" modular tissue engineering.
  • To explore methods for controlling cellular processes and tissue module formation.
  • To highlight strategies for assembling microscale units into macroscale engineered tissues.

Main Methods:

  • Surveying current techniques for controlling cell aggregation, proliferation, and extracellular matrix deposition.

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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

Related Experiment Videos

Last Updated: Jun 15, 2026

Experimental Approaches to Tissue Engineering
16:41

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
09:28

Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells

Published on: December 13, 2010

  • Examining approaches for generating shape-controlled tissue modules.
  • Reviewing methods for assembling modular microtissues into macroscale constructs.

    • Main Results:

    • Modular tissue engineering offers a promising "bottom-up" strategy for creating complex biological tissues.
    • Controlling cellular behavior and module fabrication are critical for success.
    • Assembly of microscale units enables the construction of macroscale engineered tissues.

    Conclusions:

    • Modular tissue engineering presents a viable strategy for fabricating complex biological tissues.
    • Further advancements in controlling cellular processes and module assembly are needed.
    • This approach holds significant potential for regenerative medicine and drug discovery.