Rapid determination of lithium in serum samples by capillary electrophoresis
Jennifer P Pascali1, Daniela Sorio, Federica Bortolotti
1Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy. jennifer.pascali@univr.it
Abstract:
Lithium salts are still one of the most popular therapeutic approaches to the treatment of bipolar disorders, notwithstanding the introduction of more modern, less toxic drugs. Because of a narrow therapeutic range, lithium serum concentrations must be strictly monitored during the treatment to avoid life-threatening neurotoxicity. For this purpose, methods based on flame photometry or ion-selective electrodes are usually applied. The aim of the present work was to develop and validate a simple method for the determination of lithium in serum based on capillary zone electrophoresis with indirect detection. A validation of the method was carried out, including a comparison with an automated routine method based on ion-selective electrodes.
Related Concept Videos
Electrogravimetric Analysis: Overview
To test the completeness of the...
Voltammetric Techniques: Linear-Scan (E vs Time)
Ion-Exchange Chromatography
Electrophoresis: Overview
There...
Capillary Electrophoresis: Instrumentation
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...


