Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shear Wave Elastography to Assess Respiratory Muscle Function in Congenital Myopathies.

Muscle & nerve·2026
Same author

Development and Validation of a Deep Learning-Based Facial Weakness Score for Objective Assessment in Facioscapulohumeral Muscular Dystrophy.

Muscle & nerve·2026
Same author

Health-related quality of life, pain, and fatigue in myotonic dystrophy type 2: a 13-year follow-up study.

Disability and rehabilitation·2025
Same author

Marion or the metamorphosis: a journey of self-reconstruction and hope in the face of FSHD.

Neuromuscular disorders : NMD·2025
Same author

Evaluation of echocardiography monitoring in myotonic dystrophy type 1 patients.

Frontiers in cardiovascular medicine·2025
Same author

Establishing the role of muscle ultrasound as an imaging biomarker in facioscapulohumeral muscular dystrophy.

Neuromuscular disorders : NMD·2023
Same journal

[Jaw problems and dental occlusion: is further research necessary?]

Nederlands tijdschrift voor tandheelkunde·2026
Same journal

[Dentists and oral care in Dutch-language picture books].

Nederlands tijdschrift voor tandheelkunde·2026
Same journal

[Series: Important medical-dental interactions. Oral manifestations in patients with intestinal diseases].

Nederlands tijdschrift voor tandheelkunde·2026
Same journal

[Indications for and claims to dental specialties: case studies].

Nederlands tijdschrift voor tandheelkunde·2026
Same journal

[Indications for and claims to dental specialties: regulatory framework].

Nederlands tijdschrift voor tandheelkunde·2026
Same journal

[Justification and optimization of intraoral and panoramic radiographs in oral care].

Nederlands tijdschrift voor tandheelkunde·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

[Facioscapulohumeral muscular dystrophy].

J Wilbers1, R R Frants, B G M van Engelen

  • 1Afdeling Neurologie van het Universitair Medisch Centrum St Radboud, Nijmegen.

Nederlands Tijdschrift Voor Tandheelkunde
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder causing progressive muscle weakness. Early recognition by oral health providers is crucial due to facial symptoms.

More Related Videos

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
10:28

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Related Experiment Videos

Last Updated: Jun 15, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
08:16

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
10:28

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

Area of Science:

  • Genetics
  • Molecular Biology
  • Neurology

Context:

  • Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant genetic disorder.
  • Characterized by progressive weakness in facial, shoulder, and upper arm muscles.
  • Caused by a DNA contraction on chromosome 4, leading to chromatin relaxation and gene dysregulation.

Purpose:

  • To highlight the role of oral health care providers in early FSHD recognition.
  • To emphasize the need for adequate oral health care in FSHD patients.
  • To inform about the genetic basis and clinical manifestations of FSHD.

Summary:

  • FSHD involves progressive muscle weakness, often starting with asymmetric facial muscles.
  • The genetic cause is a DNA contraction on chromosome 4, affecting chromatin structure.
  • Oral health professionals can identify early symptoms like facial weakness.

Impact:

  • Facilitates earlier diagnosis and intervention for FSHD.
  • Improves management of oral health complications associated with facial weakness.
  • Increases awareness among healthcare providers about FSHD's initial presentation.