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Multipoint linkage analysis of DXS369 and DXS304 in fragile X families
B A van Oost1, A Smits, J C Dreesen
1Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
American Journal of Medical Genetics
|February 1, 1991
Abstract:
Diagnosis of carriers of the fragile-X mental retardation gene is hampered by the paucity of tightly linked DNA markers. Recently, 2 new DNA markers RN1 (DXS369) and U6.2 (DXS304) have become available. Both markers are tightly linked to the fragile-X locus, but their location relative to the fragile site was not known with certainty. We have tested these new markers in a multipoint linkage analysis of 26 fragile-X families typed for DXS105 as a proximal marker and DXS52 as a distal marker. Our results establish the order DXS105-DXS369-fra(X)-DXS304-DXS52, which is in agreement with physical mapping results.