Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Host SNARE Proteins Mediate Lysosome and PVM Fusion to Support <i>Plasmodium</i> Liver Infection.

Cells·2026
Same author

The Putative E3 Ubiquitin Ligase TEX1 Is Required for Nuclear Biology and Developmental Progression of <i>Plasmodium berghei</i> in the Liver.

Cells·2026
Same author

Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation.

Communications biology·2024
Same author

Probing novel epitopes on the Plasmodium falciparum circumsporozoite protein for vaccine development.

NPJ vaccines·2024
Same author

LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V-ATPase and ATG16L1.

Molecular microbiology·2024
Same author

Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study.

Nature microbiology·2023

Related Experiment Video

Updated: Jun 15, 2026

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
11:36

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Imaging liver-stage malaria parasites.

Kathleen E Rankin1, Stefanie Graewe, Volker T Heussler

  • 1Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Parasitology, Hamburg, Germany. rankin@bni-hamburg.de

Cellular Microbiology
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

Microscopy reveals crucial details of the malaria parasite's liver stage. Advanced imaging techniques offer new insights into Plasmodium development before red blood cell infection.

More Related Videos

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
10:48

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics

Published on: July 28, 2015

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Related Experiment Videos

Last Updated: Jun 15, 2026

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
11:36

Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow

Published on: January 14, 2012

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
10:48

Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics

Published on: July 28, 2015

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Area of Science:

  • Parasitology
  • Cell Biology
  • Infectious Diseases

Background:

  • Malaria parasites (Plasmodium) infect liver cells (hepatocytes) before causing disease.
  • The liver stage is difficult to study biochemically due to low infection rates.
  • Parasite size during the liver stage allows for microscopic analysis.

Purpose of the Study:

  • To highlight the utility of microscopy in studying Plasmodium liver-stage development.
  • To discuss how imaging techniques have advanced understanding of key events.
  • To predict future insights from advanced microscopy in malaria research.

Main Methods:

  • Electron microscopy
  • Widefield epifluorescence microscopy
  • Laser scanning confocal microscopy
  • High-speed live video microscopy of fluorescent parasites

Main Results:

  • Microscopy enables visualization of Plasmodium liver-stage development.
  • High-speed live video microscopy has transformed the understanding of key events.
  • Imaging reveals sporozoite fate and merozoite transport via merosomes.

Conclusions:

  • Microscopy is essential for studying the Plasmodium liver stage.
  • Advanced imaging techniques provide unprecedented views of parasite development.
  • Future microscopy applications promise significant breakthroughs in malaria research.