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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Conformational preference of ChaK1 binding peptides: a molecular dynamics study.

Jiajing Zhang1, Christopher A King, Kevin Dalby

  • 1Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA. pren@mail.utexas.edu.

PMC Biophysics
|February 26, 2010
PubMed
Summary

This study used molecular modeling to investigate how the TRPM7/ChaK1 kinase interacts with its substrates. Findings suggest that substrates are unlikely to bind ChaK1 in a stable alpha-helical conformation.

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