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CCR2 and coronary artery disease: a woscops substudy
David J Dow1, Alex D McMahon, Ian C Gray
1GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK. David.J.Dow@gsk.com
BMC Research Notes
|February 26, 2010
Summary
The CCR2 Val64Ile polymorphism is not associated with coronary artery disease in the West of Scotland Coronary Prevention Study (WOSCOPS). This finding does not support a protective role for this genetic variant in atherosclerosis development.
Area of Science:
- Cardiovascular Science
- Genetics
- Immunology
Background:
- CCL2 (monocyte chemotactic protein-1) and its receptor CCR2 are implicated in atherosclerosis.
- The study investigates the role of CCR2 genetic variations in coronary artery disease (CAD).
Purpose of the Study:
- To determine the association between the CCR2 Val64Ile polymorphism and CAD.
- To evaluate the potential protective effect of CCR2 Val64Ile in the WOSCOPS cohort.
Main Methods:
- A case-control study utilizing the West of Scotland Coronary Prevention Study (WOSCOPS) sample.
- Genotyping of 443 cases and 1003 controls for the CCR2 Val64Ile polymorphism.
- Comparison of genotype frequencies between cases and controls.
Main Results:
- The CCR2 Val64Ile polymorphism showed no significant association with coronary events.
- Odds ratio for association was 1.15 (95% CI 0.82-1.61, p = 0.41).
Conclusions:
- The CCR2 Val64Ile polymorphism is not associated with CAD in the WOSCOPS study population.
- This study does not support a protective role for the CCR2 Val64Ile polymorphism in CAD development.
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