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Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease

Marcello C Bertoluci1, Alexandre S Quadros2, Rogério Sarmento-Leite2

  • 1Internal Medicine Department, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.

Diabetology & Metabolic Syndrome
|February 26, 2010
PubMed

Insights

Insulin resistance (HOMA-IR) and the triglyceride/HDLc ratio (TG/HDLc) are linked to coronary artery disease (CAD). Elevated levels of these markers, particularly their product, can help identify patients with CAD.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Vascular Biology

Background:

  • Insulin resistance is a known risk factor for cardiovascular disease.
  • Current clinical practice does not widely utilize insulin resistance as a disease marker.
  • Understanding novel markers for cardiovascular disease is crucial for early detection and intervention.

Purpose of the Study:

  • To investigate the association between homeostatic model assessment of insulin resistance (HOMA-IR) and the triglyceride/HDLc ratio (TG/HDLc) with coronary artery disease (CAD).
  • To evaluate the utility of these metabolic markers in patients undergoing cardiac catheterization.

Main Methods:

  • A cross-sectional study involving 131 patients undergoing cardiac catheterization.
  • Patients were assessed clinically, in the laboratory, and via angiography.
  • Coronary artery disease (CAD) was defined as >30% stenosis in major coronary arteries.

Main Results:

  • The prevalence of coronary artery disease (CAD) was 56.7%.
  • Patients with CAD exhibited significantly higher HOMA-IR and TG/HDLc levels compared to those without CAD.
  • Cut-off values for HOMA-IR (>6.0), TG/HDLc (>8.5), and their product (>28) demonstrated high positive predictive values for CAD, with adjusted relative risks of 1.47, 1.46, and 1.64, respectively.

Conclusions:

  • Elevated HOMA-IR and TG/HDLc, and their combined product, are positively associated with angiographically confirmed coronary artery disease (CAD).
  • These metabolic markers show potential as high-specificity tests for risk stratification in patients with suspected CAD.
Abstract

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