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Nadroparine-induced skin necrosis on a patient with essential thrombocythaemia: a case report
Manousos-Georgios Pramateftakis1, Dimitrios Kanellos, Stefanos Psomas
1Department of Surgery, European Medical Center, Asklipiou 10, 57001 Thessaloniki, Greece. mpramateftakis@hotmail.com
Abstract:
Skin necrosis is a rare but serious complication of subcutaneously administered low-molecular-weight heparin. We report a case of a 53-year-old female patient with skin necrosis induced by subcutaneous administration of nadroparine. The patient suffered from essential thrombocythaemia on a background of chronic myeloproliferative disease. She was admitted to our clinic with a subacute ileus due to endometriosis of the rectosigmoid junction. She underwent a high anterior resection and she received pre- and postoperative antithrombotic prophylaxis with subcutaneous nadroparine on a daily basis. On the 6th and 7th postoperative days, two skin necroses occurred at two injection sites.
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