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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

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Updated: Jun 15, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Obesity in pregnancy.

Gregory A L Davies1, Cynthia Maxwell2, Lynne McLeod3

  • 1Kingston ON.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

Obese pregnant women face increased risks for complications, including gestational diabetes and Cesarean birth. Pre-conception counselling and weight management are recommended for healthier pregnancies and improved maternal and fetal outcomes.

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Multidisciplinary Approach to Obesity Management: A Case Report
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Assessment of Child Anthropometry in a Large Epidemiologic Study

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A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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Published on: September 27, 2017

Multidisciplinary Approach to Obesity Management: A Case Report
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Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Public Health

Background:

  • Maternal obesity is a growing concern in pregnancy, impacting both maternal and fetal health.
  • Obesity in pregnancy is associated with a higher risk of various complications and adverse outcomes.

Purpose of the Study:

  • To synthesize evidence on the effects of maternal obesity during pregnancy.
  • To provide recommendations for the counselling and management of obese parturients.

Main Methods:

  • Comprehensive literature search of multiple databases (Statistics Canada, Medline, Cochrane Library) and grey literature.
  • Inclusion of systematic reviews, RCTs/CCTs, and observational studies, with no date or language restrictions.
  • Evidence evaluation by expert committees (Maternal Fetal Medicine and Clinical Practice Obstetric Committees of the SOGC).

Main Results:

  • Maternal obesity impacts antenatal and intrapartum care, increasing risks for maternal morbidity and mortality.
  • Obese pregnant women have elevated risks for congenital abnormalities, Cesarean delivery, and venous thromboembolism.
  • Fetal outcomes are also affected, with increased perinatal morbidity and mortality.

Conclusions:

  • Encourage pre-conception weight loss to achieve a body mass index (BMI) below 30 kg/m², ideally below 25 kg/m².
  • Obese pregnant women require counselling on weight gain, nutrition, and awareness of associated medical risks.
  • Recommendations include individualized risk assessment, consideration for anaesthesiologist consultation, and optimized fetal anatomic assessment.