Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variant Update on ASCC1 : Characterization of the First Homozygous Missense Variant Involved in Prenatal-Onset Spinal Muscular Atrophy With Congenital Bone Fractures 2.

American journal of medical genetics. Part A·2025
Same author

Characterization of gene recombination pattern induced by Tg(Crx-cre)1Tfur mouse strain in visual system organs.

Experimental eye research·2025
Same author

Atomic diffusion and mixing in old stars - VIII. Chemical abundance variations in the globular cluster M4 (NGC 6121).

Monthly notices of the Royal Astronomical Society·2024
Same author

FMR protein: Evidence of an emerging role in retinal aging?

Experimental eye research·2022
Same author

Impairment in oral medical comprehension in multiple sclerosis.

Revue neurologique·2020
Same author

Air pollution and humidity as triggering factors for stroke. Results of a 12-year analysis in the West Paris area.

Revue neurologique·2019

Related Experiment Video

Updated: Jun 15, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

[Autism, genetics and synaptic function alterations].

O Perche1, F Laumonnier, L Baala

  • 1UMR 6218, CNRS, IEM, Équipe Génétique Expérimentale et Moléculaire, Université d'Orléans, 3B, rue de la Férollerie, 45071 Orléans-La-Source cedex 2, France.

Pathologie-Biologie
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence autism spectrum disorders (ASD) and mental deficiency (MD). Research indicates a genetic continuum, suggesting shared genetic underpinnings between these neurodevelopmental conditions.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jun 15, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Area of Science:

  • Neurodevelopmental disorders
  • Genetics
  • Neurobiology

Context:

  • Autism spectrum disorders (ASD) affect language, communication, and behavior, with prevalence rates up to 1/150-1/200.
  • Mental deficiency (MD) and epilepsy frequently co-occur in individuals with autism.
  • Autism is increasingly recognized as a significant public health concern with potential genetic origins.

Purpose:

  • To explore the genetic factors contributing to autism spectrum disorders (ASD).
  • To investigate the potential genetic overlap between ASD and mental deficiency (MD).
  • To identify shared genetic targets for understanding and potentially treating these neurodevelopmental conditions.

Summary:

  • Genetic mutations, particularly those affecting the glutamate synapse, are implicated in ASD.
  • The identification of mutations in genes like NLGN4X demonstrates a genetic continuum between ASD and MD.
  • Shared genetic pathways suggest that genes involved in MD may also play a role in autism.

Impact:

  • Highlights the critical role of genetic factors in autism etiology.
  • Suggests a unified genetic approach for studying ASD and MD.
  • Opens new avenues for identifying novel genetic factors and therapeutic targets for autism.