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Related Experiment Video

Updated: Jun 15, 2026

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration

Published on: April 4, 2022

Is there a Failure to Optimize theRapy in anGina pEcToris (FORGET) study?

D H J Elder¹, M Pauriah, C C Lang

¹Department of Cardiology, Portsmouth Hospitals NHS Trust, St Mary's Hospital, Milton Road, Portsmouth PO3 6AD, UK.

QJM : Monthly Journal of the Association of Physicians

|February 26, 2010

Summary

Many patients with chronic stable angina undergoing percutaneous coronary intervention (PCI) do not meet treatment guidelines for blood pressure and heart rate control. Over half of patients did not receive adequate heart rate lowering therapy.

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Area of Science:

Cardiology
Internal Medicine

Background:

Percutaneous coronary intervention (PCI) offers symptomatic relief for chronic stable angina but does not improve prognosis.
Current guidelines advocate optimizing medical therapy before elective PCI, but adherence in practice is uncertain.

Purpose of the Study:

To assess the implementation of current treatment guidelines for chronic stable angina in the UK.
To evaluate medical therapy and risk factor modification in patients undergoing elective PCI.

Main Methods:

A multi-centre study involving six UK hospitals.
Collected data on anti-anginal drug therapy, lipid levels, blood pressure (BP), and heart rate (HR) control in patients undergoing elective PCI for chronic stable angina.

Main Results:

85% of 500 patients received statins, and 76% were on ACE inhibitors or ARBs.
78% received beta-blockers, but 27% had resting HR ≥70 bpm, indicating inadequate HR control in many.
While BP targets were met by many, 50% had systolic BP <130 mmHg and 76% had diastolic BP <80 mmHg.

Conclusions:

A significant proportion of patients undergoing elective PCI for chronic stable angina do not achieve therapeutic targets for lipid, BP, and HR control.
Over 50% of patients did not receive adequate anti-anginal therapy to reach recommended resting HR targets.